Musim kedua mencerminkan kehidupan putri Anandi, Dr. Nandini (alias Nimboli) yang juga seorang pengantin anak. Balika Vadhu dikreditkan sebagai drama India pertama yang menyelesaikan 2000 episode. Pertunjukan dibagi menjadi dua bagian berjudul Balika Vadhu – Kacchi Umar Ke Pakke Rishte (Bahasa Indonesia: Pengantin Anak – Hubungan Kuat dengan Usia Lembut), dan Balika Vadhu – Lamhe Pyaar Ke (Bahasa Indonesia: Pengantin Anak – Saat-saat Cinta). Musim kedua, Balika Vadhu 2 ditayangkan pada 9 Agustus 2021. Dibintangi oleh Vansh Sayani dan Shreya Patel.
Kisah Anandhi dimulai dalam kehidupan yang jauh dari sederhana di sebuah desa kecil di kawasan Rajastan. Ia tinggal bersama keluarga kecilnya. Tentu saja, kesempatan Anandhi untuk bersekolah tertutup rapat. Tidak ada kata lain selain menerima tawaran ini. Ia dipaksa menikah dengan Jagdish, anak dari Sumitra dan Bhairon. Bhairon adalah anak dari Kalyani Devi, seorang terpandang di kawasan tersebut. Karena itulah, Anandhi harus mau menjadi anggota keluarga tersebut, karena kedua orang tuanya tidak mampu lagi membiayai kebutuhan hidupnya
Avika Gor as Anandi Khajaan Singh / Young Anandi Jagdish Singh (2008-2010)
Avinash Mukherjee as Young Jagdish Bhairon Singh / Jagya (2008-2010)
Surekha Sikri as Kalyani Devi Dharamveer Singh/Dadisa (2008-2016) (Dead)
Pratyusha Banerjee / Toral Rasputra as Anandhi Jagdish Singh / Anandhi Shivraj Shekhar (Dead)
Shashank Vyas/Shakti Anand as Dr. Jagdish Bhairon Singh/Jagya/Jagat (2010-2015)/(2015-2016) (Dead)
Sriti Jha/Sargun Mehta/Aasiya Kazi as Dr. Ganga Jagdish Singh (2013)/(2013-2014)/(2014-2016) (Dead)
Siddharth Shukla as Shivraj Alok Shekhar/Shivraj Anoop Shekhar/Shiv (2012-2015) (Dead)
Gracy Goswami as Young Nandini Shivraj Shekhar/Nimboli Kundan Singh (2015-2016)
Mahima Makwana / Anjum Farooki / Deblina Chatterjee as Gudiya / Dr. Gauri Jagdish Singh / Gauri Singh (2009) / (2010-2012) / (2014) (Dead)
Anup Soni as Bhairon Dharamveer Singh (2008-2014) (Dead)
Smita Bansal as Sumitra Bhairon Singh (2008-2014) (Dead)
Satyajit Sharma as Basant Dharamveer Singh/Basant Mahaveer Singh (2008-2014) (Dead)
Neha Marda/Sheetal Khandal as Gehna Basant Singh/Gehna Niranjan (2008-2012)/(2012-2015) (Dead)
Sanjay Basak as Nandikishor Basant Singh/Nandu (2012-2015) (Dead)
Viren Vazirani as Young Shivam Shivraj Shekhar (2015-2016)
Sunil Singh as Akhiraj Singh (2015-2016) (Dead)
Sparsh Shrivastav/Karan Pahwa as Kundan Akhiraj Singh (2015-2016)
Tisha Kapoor as Urmila Kundan Singh (2015-2016) (Dead)
Fikram Amal Tomagola as Varun Shyam Singh ( 2014-2015 ) (Dead)
Sudhir Pandey as Premkishore Shekhar (2012-2015) (Dead)
Sushmita Mukherjee as Subhadra (2014-2015) (Dead)
Sonal Jha as Iravati Alok Shekhar (2012-2015) (Dead)
Anita Kulkarni as Meenakshi Anoop Shekhar (2012-2015) (Dead)
Avinash Wadhawan/Akshay Anand as Anoop Premkishor Shekhar (2012-2015) (Dead)
Roop Durgapal as Sanchi Vivek Kabra (2012-2015) (Dead)
Mohit Abrol as Anuj (2014)
Vimarsh Roshan as Advocate Vivek Roshan Kabra (2013-2015) (Dead)
Abhishek Tiwari as Mahi Anoop Shekhar (2012-2014) (Dead)
Chandresh Singh as Ratan Singh (2013-2015) (Dead)
Vibha Anand/Janvi Chheda as Sugna Shyam Singh (2008-2011)/(2011-2013) (Dead)
Vikrant Massey/Sachin Shroff as Shyam Madan Singh (2009-2011)/(2011-2013) (Dead)
Rajeshwari Sachdev as Mangala Devi Singh/Disa (2015-2016) (Dead)
Farah Hussain as Kamli Akhiraj Singh/Kamli Pushkar Singh (2015-2016) (Dead)
Rishi Dev as Gopal (2015) (Dead)
Rajendra Gupta as Mahaveer Singh (2009-2012) (Dead)
Parichay Sharma as Pushkar Jata Shankar Singh (2015-2016)
Hiten Tejwani as Dr. Anant (2015-2016)
Chetanya Adib as Khajaan Singh (2008-2015) (Dead)
Bhairavi Raichura as Bhagwati Khajaan Singh (2008-2012) (Dead)
Farida Jalal as Vsundhara Devi/Badi Jiji (2009, 2012) (Dead)
Farnaz Shetty as Kanchan (2013) (Dead)
Nivedita Bhattacharya as Shivani Rajadhyaksha (2011) (Dead)
Harsh Chhaya as Palash Scindia (2014) (Dead)
Kamalika Guha Thakurta as Pramila (2014) (Dead)
Sadiya Siddiqui as Sandhya/Teacher ji (2008-2014) (Dead)
Sakshi Tanwar as Teepri (2010) (Dead)
Shivshakti Sachdev as Champa (2008-2010) (Dead)
Mahhi Vij as Dr. Nandini Krish Malhotra/Dr. Nandini Shekhawat/Nandini Shivraj Shekhar (2016)
Ruslaan Mumtaz as Krish Malhotra (2016)
Vineetth Kumar as Abhayram/Kundan Akhiraj Singh (2016) (Dead)
Dishank Arora as Shivam Shivraj Shekhar/Shankar Singh (2016)
Yukti Kapoor as Sudha Shekhawat/Sudha Premal Singh (2016)
Sonia Shah as Karuna; Krish's mother & Abhayram's wife (2016)
Nimisha Vakharia as Triveni, Karuna's sister (2016)
Avinash Sachdev as Dr. Amit Naresh Goel (2016)
Smriti Khanna as Vandana Amit Goel / Vandana Mittal (2016)
Shahab Khan as Mr. Shekhawat (2016)
Neetu Pandey as Jamuna Shekhawat (2016) (Dead)
Ayush Anand as Premal(2016)
Hetal Yadav as Premal's mother (2016) (Dead)
Prithvi Sankhala as Dr. Naresh Goel (2016) (Dead)